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 姓名:  袁广银
 职称:  教授
 博导/硕导:  博导、硕导
 所属二级机构:   轻合金研究所
 通讯地址:  上海市闵行东川路800号永利皇宫会员注册登录院
 邮编:  200240
 E-mail:  gyyuan@sjtu.edu.cn
 联系电话:  021-34203051
从事专业: 材料科学与工程
学习与工作简历:

2000.2毕业于东南大学,获博士学位。博士论文被评为江苏省优秀博士论文。 2000.3-2001.12 上海交大永利集团博士后,从事汽车用耐热镁合金的应用基础研究,获永利集团优秀博士后奖励基金一等奖。

2001.12-2008.12 上海交大永利集团副教授,硕士生导师,从事镁合金材料的研究和教学。

2008.12-至今 永利皇宫会员注册登录院教授、博士生导师,从事可降解医用金属材料及其表面改性的研究和教学工作。

其中:2002.9-2004.9 荣获日本学术振兴会(JSPS)研究奖学金,在日本東北大学金属材料研究所与国际著名材料专家、日本科学院院士、美国工程院外籍院士井上明久教授合作,从事超高强度镁材料的研究工作。

2011.7-2011.9 日本東北大学金属材料研究所访问教授,从事新型金属材料的合作研究。

研究方向一 生物可降解医用金属材料及其表面工程
研究方向二 新型金属材料的组织控制与强韧化
研究情况

5年作为项目负责人先后主持承担了国家重点研发专项“新型全降解锌合金血管支架研发及其临床应用基础研究”、十二五863课题“新型可控降解骨修复用镁合金材料研发”、科技部十二五科技支撑项目:“全降解镁合金血管支架”、上海市基础研究重大项目“可降解骨内植物用镁基生物材料相关重大问题的基础研究”以及三项国家自然基金项目等课题的研究工作。合著“镁合金科学与技术”(科学出版社,2007)和“可降解金属”(科学出版社,2016)。共发表材料研究领域学术论文140余篇, 其中SCI收录100余篇, 被引用4000余次,多次应邀参加国际学术会议作Keynote主题发言。申请发明专利40余项(其中授权25项,实现企业转让12)。荣获2007年上海市科技进步一等奖、2008上海市发明创造专利奖三等奖各一项。入选2007年教育部新世纪优秀人才, 2017年上海市优秀学术带头人支持计划,荣获2008年度永利集团“晨星青年学者奖励计划”SMC优秀青年教师奖和2013-2014学年永利集团优秀教师奖。

讲授主要课程

本科生课程:《工程材料学》 、《工程材料性能和选用》

硕士/博士研究生课程:《生物医用材料》、《智能生物医用材料》

教学研究 担相关本科生和研究生的课程教学,采用“将相关材料的前沿研究与基础理论教学紧密结合”的授课方式,融合自己的研究体会,培养学生独立思考和对知识体系的融汇贯通、触类旁通的能力,引导学生积极参与课程的讨论环节,受到历届学生们的欢迎。
代表性论文、论著

1. 丁文江,袁广银,王渠东等. 镁合金科学与技术,北京:科学出版社,2007

2. 郑玉峰,杨柯,袁广银等,可降解金属(下),科学出版社,北京,2016

3. Zhe Wang, Xinyuan Wang, Yuan Tian, Jia Pei, Jian Zhang, Chang Jiang, Junming Huang, Zhiying Pang, Yuanwu Cao, Xiuhui Wang, Senbo An, Xiao Wang, Hua Huang***, Guangyin Yuan**, Zuoqin Yan*, Degradation and Osteogenic Induction of a SrHPO4-coated MgNdZnZr Alloy Intramedullary Nail in a Rat Femoral Shaft Fracture Model, Biomaterials, 247 (2020)119962.

4. Chenxin Chen, Jiahui Chen, Wei Wu, Yongjuan Shi, Liang Jin, Lorenza Petrini, Li Shen, Guangyin Yuan,* Wenjiang Ding, Junbo Ge, Elazer R. Edelman, Francesco Migliavacca*, In vivo and in vitro evaluation of a biodegradable magnesium vascular stent designed by shape optimization strategy, Biomaterials 221 (2019) 119414

5. Hui Qin, Yaochao Zhao, Zhiquan An, Mengqi Cheng, Qi Wang, Tao Cheng, Qiaojie Wang, Jiaxing Wang, Yao Jiang, Xianlong Zhang, Guangyin Yuan*, Enhanced antibacterial properties, biocompatibility, and corrosion resistance of degradable Mg-Nd-Zn-Zr alloy, Biomaterials, 53(2015)211-220

6. L Jin, CX Chen, GZ Jia, YT Li, J Zhang, H Huang, B Kang, GY Yuan*, H Zeng*, TX Chen*, The bioeffects of degradable products derived from a biodegradable Mg-based alloy in macrophages via heterophagy, Acta Biomater, 106(2020)428-438

7. Guoyuan Li, Lei Zhang, Lei Wang, Guangyin Yuan, Kerong Dai, Jia Pei*, Yongqiang Hao*, Dual modulation of bone formation and resorption with zoledronic acidloaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: An in vitro and in vivo study, Acta Biomater. 652018486-500.

8. Jian Zhang, Haiyang Li, Wu WangHua Huang, Jia Pei, Haiyun QuGuangyin YUAN*, Yongdong Li*, The degradation and transport mechanism of a Mg-Nd-Zn-Zr stent in rabbit common carotid artery: a 20-month study, Acta Biomater., 69(2018)372-384.

9. K Zhou, YT Li, L Zhang, L Jin, F Yuan, JY Tan*, GY Yuan*, J Pei*,  Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium, Bioactive Materials, 6(1)(2021): 262-272

10. Hongwei Miao, Hua Huang*, Shihao Fan, Jinyun Tan, Zhongchang Wang*, Wenjiang Ding, Guangyin Yuan,*Nanoscale Precipitations in Deformed Dilute Alloying Mg-Zn-Gd AlloyMaterials & Design, 2020, 196, 109122

11. Chun Chen , Rui Yue , Jian Zhang , Hua Huang *, Jialin Niu *, Guangyin Yuan*, Biodegradable Zn-1.5Cu-1.5Ag alloy with anti-aging ability and strain hardening behavior for cardiovascular stentsMater Sci & Eng C.2020116,111172

12. R. Yue, J. Niu, Y. Li, G. Ke, H. Huang, J. Pei, W. Ding, G. Yuan, In vitro cytocompatibility, hemocompatibility and antibacterial properties of biodegradable Zn-Cu-Fe alloys for cardiovascular stents applicationsMater Sci & Eng C. 113 (2020) 111007

13. Lei Zhang, Gaozhi Jia, Min Tang, Chenxin Chen, Jialin Niu, Hua Huang, Bin Kang, Jia Pei*, Hui Zeng*, Guangyin Yuan*Simultaneous enhancement of anti-corrosion, biocompatibility and antimicrobial activities by hierarchically-structured brushite/Ag3PO4-coated Mg-based alloy scaffoldsMater Sci & Eng C. 111(2020) 110779

14. Yinchuan Wang, Hua Huang, Gaozhi Jia, Jian Zhang, Guangyin Yuan*, Effect of grain size on the mechanical properties of Mg foams, Journal of Materials Science and Technology, Volume 58, 1 December 2020, Pages 46-54

15. Wei Wang, Gaozhi Jia, Qing Wang, Hua Huang, Xiaolin Li, Hui Zeng, Wenjiang Ding, Frank Witte, Changqing Zhang*, Weitao Jia*, Guangyin Yuan*, The in vitro and in vivo biological effects and osteogenic activity of novel biodegradable porous Mg alloy scaffolds, Materials and Design, 189(2020)108514

16. Dandan Zhang, Ni Ni, Yun Su, Hongwei Miao, Zhimin Tang, Yongrong Ji, Yuyao Wang, Huiqin Gao, Yahan Ju, Na Sun, Hao Sun, Guangyin Yuan, Yinchuan Wang, Huifang Zhou, Hua Huang,* Ping Gu,* and Xianqun Fan*, Targeting Local Osteogenic and Ancillary Cells by mechanobiologically optimized magnesium scaffolds for orbital bone reconstruction in Canines. ACS applied materials & interfaces 2020;12: 27889-904

17. Rui Yue, Jian Zhang, Guizhou Ke, Gaozhi Jia, Hua Huang, Jia Pei, Bin Kang, Hui Zeng, Guangyin Yuan, Effects of extrusion temperature on microstructure, mechanical properties and in vitro degradation behavior of biodegradable Zn-3Cu-0.5Fe alloy, Materials Science & Engineering C (2019),105, 110106

18. Wenlong Lu, Rui Yue, Hongwei Miao, Jia Pei, Hua Huang*, Guangyin Yuan*, Enhanced plasticity of magnesium alloy micor-tubes for vascular stents by double extrusion with large plastic deformation, Materials Letters 245,2019:155-157

19. Liang Jin, Chenxin Chen, Yutong Li, Feng Yuan, Ruolan Gong, Jing Wu,Hua Zhang, Bin Kang, Guangyin Yuan*, Hui Zeng* and Tongxin Chen*A Biodegradable Mg-Based Alloy Inhibited the Inflammatory Response of THP-1 Cell-Derived Macrophages Through the TRPM7PI3KAKT1 Signaling AxisFrontiers in ImmunologyDecember 2019 | Volume 10 | Article 2798

20. L Jin, J Wu, G Yuan*, T Chen*, In vitro study of the inflammatory cells response to biodegradable Mg-based alloy extract, PloS one 2018, 13 (3), e0193276

21. Gaozhi Jia#, Chenxin Chen#, Jian, Zhang, Bérengère J.C. Luthringer - Feyerabend, Regine Willumeit-Roemer, Hua Zhang, Meiping Xiong*, Hua Huang*, Guangyin Yuan* Frank Feyerabend*, In vitro degradation behavior of Mg scaffolds with three-dimensional interconnected porous structures for bone tissue engineeringCorrosion Science1442018301-312.

22. Y Hou, G Jia, R Yue, C Chen, J Pei, H Zhang, H Huang*, M Xiong, G Yuan*, Synthesis of biodegradable Zn-based scaffolds using NaCl templates: Relationship between porosity, compressive properties and degradation behavior, Materials Characterization 137(2018), 162-169

23. Gaozhi Jia, Yi Hou, Chenxin Chen, Jialin, Niu, Hua Zhang, Hua Huang,*, Meiping Xiong, Guangyin Yuan* Precise fabrication of open porous Mg scaffolds using NaCl templates: relationship between space holder particles, pore characteristics and mechanical behaviorMaterials & Design140(2018) 106-113

24. XiangdongKong, LeiWang,GuoyuanLi,XinhuaQu,JialinNiu, Tingting Tang, Kerong Dai, Guangyin Yuan*, Yongqiang Hao*Mg-based bone implants show promising osteoinductivity and controllable degradation: A long-term study in a goat femoral condyle fracture modelMaterials Science & Engineering C.86201842-47

25. Lin Mao, Li Shen, Jiahui Chen, Xiaobo Zhang, Minsuk Kwak, Yu Wu, Rong Fan, Lei Zhang, Jia Pei, Guangyin Yuan*, Chengli Song*, Junbo Ge, Wenjiang Ding, A promising biodegradable magnesium alloy suitable for clinical vascular stent applicationScientific Reports, 7, 463432017; doi:10.1038/srep46343(2017).

26. Zibo Tang, Jialin Niu, Hua Huang*, Hua Zhang, Jia Pei, Jingmin Ou, Guangyin Yuan*, Potential biodegradable Zn-Cu binary alloys developed for cardiovascular implant applications, J Mech Behav Biomed Mater. 2017;72:182-91

27. Yongjuan Shi, Jia Pei *, Lei Zhang, Byung Kook Lee, Yeonhee Yun, Jian Zhang, Zhonghua Li, Song Gu, Kinam Park, Guangyin Yuan*, Understanding the effect of magnesium degradation on drug release and anti-proliferation on smooth muscle cells for magnesium-based drug eluting stents, Corrosion Science, 2017 123:297-309

28. Hongwei Miao, Hua Huang, Yongjuan Shi, Hua Zhang, Jia Pei, Guangyin Yuan*, Effects of solution treatment before extrusion on the microstructure,mechanical properties and corrosion of Mg-Zn-Gd alloy in vitro, Corrosion Science, 2017,12290-99

29. Yongjuan Shi, Jia Pei, Jian Zhang, Jialin Niu, Hua Zhang, Shengrong Guo, Guangyin Yuan*, Enhanced corrosion resistance and cytocompatibility of biodegradable Mg alloys by introduction of Mg(OH)2 particles into poly (L-lactic acid) coating", Scientific Reports, 2017, 7:41796

30. Zibo Tang, Hua Huang*, Jialin Niu, Lei Zhang, Hua Zhang, Jia Pei, Jinyun Tan, Guangyin Yuan*, Design and characterizations of novel biodegradable Zn-Cu-Mg alloys for potential biodegradable implants, Materials and Design, 2017;117:84-94.

31. Lei Zhang#, Jia Pei#*Haodong Wang, Yongjuan Shi,  Jialin Niu, Feng Yuan, Hua Huang, Hua Zhang, Guangyin Yuan*A facile preparation of poly(lactic acid)/brushite bi-layer coating on biodegradable magnesium alloys with multiple functionalities for orthopedic application. ACS Applied Materials & Interfaces, 2017, 9(11): 9437-9448

32. Yongjuan Shi, Lei Zhang, Jiahui Chen, Jian Zhang, Feng Yuan, Li Shen, Chenxin Chen, Jia Pei, Zhonghua Li, Jinyun Tan, Guangyin Yuan*,In vitro and in vivo degradation of rapamycin-eluting Mg-Nd-Zn-Zr alloy,stents in porcine coronary arteries, Materials Science and Engineering C 80 (2017) 16

33. Wu Wang, Yong-Li Wang, Mo Chen, Liang Chen, Jian Zhang, Yong-Dong Li*, Ming-Hua Li*, Guang-yin Yuan*, Magnesium alloy covered stent for treatment of a lateral aneurysm model in rabbit common carotid artery: An in vivo study, Scientific Reports 2016,6,37401; doi:10.1038/srep37401(2016)

34. Jialin Niu , Meiping Xiong, Xingmin Guan, Jian Zhang, Hua Huang, Jia Pei, Guangyin Yuan* ,The in vivo degradation and bone-implant interface of Mg-Nd-Zn-Zr alloy screws: 18 months post-operation results, Corrosion Science, 113(2016):183-187.

35. J. Niu, Z. Tang, H. Huang, J. Pei, H. Zhang, G. Yuan*, W. Ding. Research on a Zn-Cu alloy as a biodegradable material for potential vascular stents application. Materials Science & Engineering C. 2016;69:407413.

36. J. Zhang, S. Hiromoto, T. Yamazaki, J. Niu, H. Huang, G. Jia, H. Li, W. Ding, G. Yuan*. Effect of macrophages on in vitro corrosion behavior of magnesium alloy. Journal of Biomedical Materials Research Part A. 2016,104A:2476-2487.

37. Zhenhua Chu, Guangyin Yuan*, Hidemi Kato, Guoqiang Xie, Dianran YanThe effect of size and volume fraction of the reinforcement on mechanical property and deformation mechanism of the bulk metallic glassy composite, Journal of Alloys and Compounds 644(25),2015,25-29

38. L Mao, L Shen, J.H. Chen, Y Wu, M Kwak, Y Lu, Q Xue, J Pei, L Zhang, G.Y. Yuan*, R Fan, J.B. Ge, W.J. Ding, Enhanced bioactivity of Mg-Nd-Zn-Zr alloy achieved with nanoscale MgF2 surface for vascular stent application, ACS Appl. Mater. Interfaces 2015,75320-5330

39. Fei Liu, Chenxin Chen, Jialin Niu, Jia Pei, Hua Zhang, Hua Huang, Guangyin Yuan*, The processing of Mg alloy micro-tubes for biodegradable vascular stents, Materials Science & Enginnering. C, 2015, 48: 400-407.

40. Xingmin Guan, Meiping Xiong, Feiyue Zeng, Bin Xu, Lingdi Yang, Han Guo, Jialin Niu, Jian Zhang, Chenxin Chen, Jia Pei, Hua Huang, Guangyin Yuan*, The enhancement of osteogenesis and biodegradation control by brushite coating on Mg-Nd-Zn-Zr alloy for mandibular bone repair, ACS Applied Materials Interfaces, 2014, 6: 21525-21533. 

毕业博士生数 12
毕业硕士生数 16
参加学术团体、任何职务

2019.11月当选为中国生物材料学会医用金属分会副主任委员;

2018.3月当选为中国医学装备协会医用增材制造分会常务理事

2017年3月当选为中国医疗器械行业协会心脑疾病介入治疗产业分会常务理事

2015年6月聘为复旦大学教育部心血管介入治疗技术与器械工程研究中心技术委员会委员;

2013年6月当选中国材料研究学会青年委员会常务理事 

申请专利

1)G Yuan, C Chen, W Wu, M Francesco, Biodegradable metallic vascular stent and application thereof, United States Patent , Patent No. US10463513B2,Date of Patent:11/05/2019.

2G Yuan, W Ding, Biodegradable magnesium alloy nerve conduit for nerve defect repair and its preparation method. United States Patent , Patent No.US10792391, Date of Patent: 10/06/2020

3袁广银,陈晨忻,吴卫,弗朗西斯科.米利亚瓦卡,一种生物可降解金属血管支架及其应用,中国发明专利号:ZL201510427276.2

4)裴佳史永娟 元峰 袁广银,用于镁基医用材料及器件的仿生多功能涂层及制备、用途,中国发明专利号:ZL201510564506.X.

5)裴佳、张磊、袁广银,可降解镁基骨内植物可载药高分子钙磷复合涂层及制备,中国发明专利号:ZL201510351233.0

6)黄华,袁广银,生物可降解的医用锌铜合金及其制备方法和用途,中国发明专利号:ZL201510512800.6

7)黄华,袁广银,神经缺损修复用可降解锌合金神经导管及其制备方法,中国发明专利号:ZL 201610756193.2

8)黄华,唐子波,袁广银,生物医用可降解锌合金毛细管材的制备方法及其应用,中国发明专利号:ZL201610828270.0.

9)袁广银,贾高智,一种三维连通多孔镁基材料的制备方法及其用途,中国发明专利号:ZL201510395799.3

10)袁广银,丁文江, 可弯曲全降解镁合金神经导管及其制备方法, 中国发明专利号:ZL201410345554.5.

11)袁广银,丁文江, 用于神经缺损修复的可降解镁合金神经导管及其制备方法, 中国发明专利号:ZL201410258445.X

12)袁广银, 刘飞, 朱永奎, 生物可降解镁合金血管内支架用毛细管的精密加工方法, 中国发明专利号:ZL201310327209.4

13) 袁广银, 牛佳林, 医用可降解Fe-Mg二元合金材料及其制备方法, 中国发明专利号:ZL201210585520.4

14) 袁广银, 牛佳林, 医用可降解Fe-Mg-X合金材料及其制备方法, 中国发明专利号:ZL201210585516.8

15) 袁广银,章晓波,丁文江,骨科用镁合金内植入材料及其制备方法,中国发明专利号:ZL201010252357.0

16) 袁广银,章晓波,丁文江,生物体内可降解镁合金血管内支架的制备方法,中国发明专利号:ZL201010204716.5

17) 袁广银,章晓波,丁文江,生物体内可降解高强韧耐蚀镁合金内植入材料,中国发明专利号:ZL201010204719.9

18) 袁广银, 李治国, 牛佳林, 章晓波, 丁文江, 骨内植物用镁合金表层制备生物活性透钙磷石涂层的方法, 中国发明专利号:ZL201110086203.3,

19) 袁广银,尹健,丁文江,快速凝固超高强度镁合金及其制备方法,中国发明专利号:ZL200910049871.1

20) 袁广银,刘勇,丁文江,自生准晶增强的高塑性变形镁合金,专利号:ZL 200610026842.X 

荣誉和奖励

1) 入选2007年教育部新世纪优秀人才支持计划

2) 2007年度上海市科学技术发明奖一等奖 (“新型高性能耐热镁合金研制及其在汽车上的应用”,第三获奖人)

3) 2008上海市发明创造专利奖三等奖(“汽车用多元耐热镁合金及其熔铸工艺”,第一获奖人)

4) 2008永利集团“晨星青年学者奖励计划”SMC优秀青年教师奖

5) 2013-2014学年永利集团优秀教师奖

6) 日本学术振兴会(JSPS)研究奖学金(2002.9-2004.9)

7) 永利集团优秀博士后奖励基金一等奖

8) 博士论文被评为第五届江苏省优秀博士论文。

其他
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